DeVoodoo's pick: 49ers
Of any team who lost in week one, no team suffered through more humiliation than the 49ers (who were decimated by Pete Carroll's Seahawks). Look for that sting of defeat to fuel a nice bounce-back performance against the defending world champs.
Every statistical and logical derivative says the Saints should wipe their asses with the 'Niners, but at the end of the day, this game is about fight. And I'm expecting the 49ers to embody their head coach's will to win and do enough to slow down the Saints passing attack.
But the real surprise of the night might be the 49ers offense. Look for a surprisingly effective performance from Alex Smith and the passing game.

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